Continuous flow synthesis of phenyl glucosazone and its conversion to 2H-1,2,3-Triazole building blocks

Abstract A continuous flow approach for the generation of phenyl glucosazone from glucose and hydrazine is reported giving pure target in 53% isolated yield. This thermal process generates product as an insoluble material that causes reactor fouling via adhering to walls. To overcome this issue a segmented was realised whereby streams air reaction solution were combined T-piece directed through heated coil. The resulting micro-mixing prevented blocking allowed multi-hour reactions generate desired high value demonstrated its oxidative cyclisation into 2 H -phenyl-1,2,3-triazoles which represent important heterocyclic scaffolds.